Gangrene occurs when significant tissue dies as a result of injury or infection. Such cell death, or necrosis, usually results from a reduction of blood supply to the tissue.
During World War I, gas gangrene, caused by bacterial infection, complicated 6% of open fractures and 1% of open wounds.
Maggot Therapy was used to cure gangrene. Live, disinfected maggots (fly larvae) were inserted into the wound to feed on and clean out the necrotic tissue.