Like Silas, Miss Lupescu is a "solitary type". A clue to her identity is given in her name: Lupescu is a well-known Romanian surname derived from "lup", the Romanian word for "wolf".
Although werewolves are generally portrayed negatively in legend, Gaiman's "Hound of God", like his vampire, is a force for good.
"Hound of God" is also a name associated with the founder of the Dominican religious order. In iconography, St. Dominic is most often portrayed with a dog. This Domini Canis, or "Hound of God", is said to reflect the Dominican spirit of study, inquiry, and pursuit of truth. Miss Lupescu, a stern but faithful instructor, exemplifies this ideal.
Taurus is another constellation, very close to Orion, whose name is the Latin word for "bull".
Gaiman is aping the "long s" which was used in preference to the more familiar short s when the letter came at the start or in the middle of a word. It fell out of use in Britain around the turn of the nineteenth century.
Before the discovery of chemical elements or particle physics, it was believed everything was made of the elements of fire, water, air, ether and earth in different proportions and combinations. This idea came from Ancient Greek philosophy and was common until the late eighteenth century.
In the same period, the health and function of the body was believed to be governed by the four humours: black bile, yellow bile, phlegm and blood. Imbalances of humours led to sickness and different types of disposition. This theory was first put forward by Hippocrates and was widely believed (even by doctors) until the nineteenth century.
Listen on Spotify: The Hut on Fowls' Legs from Pictures at an Exhibition by Mussorgsky