The Sistine Madonna is a painting by the Italian Renaissance artist Raphael. It is perhaps now best known for the two putti who appear at the bottom, and whose images are often reproduced independently to the rest of the painting.
On a somewhat unrelated note, these putti are often mistakenly called cherubs. A cherub, in the original sense, is a terrifying form of angel originating from the Assyrian karabu, human-headed winged bulls who guarded the entrance to temples. The Bible retains these supernatural figures as guardians of Paradise. Over time, the word cherubim has slipped in meaning until it is equated with putti, the baby or toddler-aged angels who are far less terrifying to behold.